Section I. The Causes of Psychosis: 1. Introduction; 2. Methods; 3. Delirium; 4. Neurodevelopmental disorders and chromosomal abnormalities; 5. Neurodegenerative disorders; 6. Focal neurological disease; 7. Malignancy; 8. Infectious and postinfectious syndromes; 9. Endocrine disease; 10. Inborn errors of metabolism; 11. Nutritional deficiency; 12. Other acquired metabolic disorders; 13. Autoimmune rheumatic disorders and vasculitides; 14. Other autoimmune encephalopathies; 15. Poisoning; 16. Sleep disorders; 17. Sensory deprivation and impairment; 18. Miscellaneous; 19. Catatonia; 20. Agitation and bizarre behaviour; 21. Primary psychiatric disease; 22. Factitious disorder and malingering; 23. Multiple simultaneous causes of psychosis, and questions of causality; Part II. A Clinical Approach to the Diagnosis of Psychosis: 24. History and examination; 25. Initial investigations relevant to psychosis; 26; Putting it together: clinical and paraclinical clues; 27. Further investigations relevant to psychosis; 28. Classificatory approach for psychosis of unknown aetiology; 29. Conclusion.